Antioxidant, anti-inflammatory, and antibacterial activities of a 70% ethanol-Symphyocladia linearis extract

Research on the potential biological activity of red alga Symphyocladia spp. has been limited to latiuscula, which is widely used as a food ingredient in Korea. Here, we examined another species, linearis, found Korea and was reported new species 2013. The aim this study evaluate antioxidant, anti-inflammatory, antibacterial properties 70% ethanol extract S. linearis. Antioxidant activity, evaluated using radical scavenging assays, revealed half maximal inhibitory concentration values for 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) 2,2?-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) 34.57 11.70 ?g/mL algal extract, respectively. Anti-inflammatory linearis ethanolic RAW 264.7 cells by measuring inhibition lipopolysaccharide-induced nitric oxide (NO) prostaglandin E2 (PGE2) production. cytotoxicity NO PGE2 first examined, confirming no toxicity at concentrations ranging from 10-100 ?g/mL. production inhibited 61.1% 78.0% 50 100 respectively; 69.1%, 83.2%, 94.8% 25, 50, Thus, showed very strong efficacy against cellular reactive oxygen measured 2?,7?-dichlorofluorescin diacetate fluorescence, 48.8% addition extract. Antibacterial disc diffusion method minimum (MIC). effective only gram-positive bacteria, exhibiting Staphylococcus aureus with MIC 256 Bacillus cereus 1,024 Based these results, infer that possesses anti-inflammatory properties, therefore be prevention treatment inflammatory immune diseases.